Medscapes clinical reference is the most authoritative and accessible point of care medical reference for physicians and healthcare professionals, available online and via all major mobile devices. Evaluation of commercial antacids using the data given below fill in the blanks and calculate the cost per mole of base in the antacid tablet. Jul 31, 2015 the sample size for this study was estimated based on the results of an earlier pilot study ga1203 conducted in the uk. Jul 22, 2015 acid neutralizing capacity anc of antacids is an important indicator of the efficacy of such products. A comparative study on palatability and cost effectiveness sadia nasim1, muhammad ayaz mustufa2, syed ijaz hussain zaidi3, muhammad tanweer khan4, abdul wajid 5 abstract objective. Effectiveness of commercial antacids essay 615 words. A comparative study of the acid neutralizing capacity of various commercially available antacid formulations in libya article pdf available january 2010 with 484 reads how we measure reads. As a widely used antacid, calcium carbonate has been studied. Scribd is the worlds largest social reading and publishing site. A comparative study of the acid neutralizing capacity of various commercially available antacid formulations in libya prakash katakam, noha m.
For equivalent volumes of antacids, there was a 50%difference in costbetweenthecheapestandmost expensive products. How to make a project on comparative study on antacids. Then the ph meter stick would change color depending. Since the purpose of this lab is to measure the amount of hcl neutralized from the addition of various antacids, it is not necessary to add the digestive enzymes to the solution. Part b cent and scent analysis 1 record the posted data regarding the cost of various bottles of antacids, and the number of doses contained in each bottle in the data table. There was a considerable range of judgements about palatability, but preference. Doc comparitive study of commercial antacids cbse class. Determination of the amount of acid neutralized by an antacid.
Scientific edition a comparative in vivo study of antacids ii study of antacids ii lawall and harrisson research laboratories, philadelphia 3, pa. Antacids the stomach secretes hydrochloric acid, which is necessary for digestion of food. These substances are used to neutralize overdose of stomach acid and thus ease symptoms of heart burn. Introduction antacids are medications taken to temporarily relieve heartburn or indigestion. This study is based on the evaluation of acid neutralizing capacity of five different commercial brands of antacid tablets. Detroit meeting april 1956 this study was made under a research grant by the american chicle company, new york and the chattanooga medicine co. There are several types of commercial antacids which prevent heart burn and stomach ulcers depending on their effectiveness. It operates by generating intermediate comparison acrobat 9 clone which is then compiled to a native invalidop. After you mixed every beaker use the ph meter to see the level of acidity. You will need to perform the same calculations for your laboratory data.
Comparison of the effect of the antacid rennie versus low. Four antacid preparations have been studied in a stratified, randomized, doubleblind trial to evaluate criteria which determine patients acceptance of this type of therapy. They are used to relieve acid indigestion, upset stomach, sour stomach, and heartburn. Experiment ten titrations of commercial antacids objectives. Theyre available over the counter from pharmacies and are often used to treat the symptoms of heartburn and indigestion. But it might surprise you to learn that, over the past 15 years or so, some makers of ice cream and many other processed foodsfrom pasta to ground beef productshave changed their recipes to swap out some of the table sugar sucrose with a sweeteningtexturizing ingredient called trehalose that depresses the. Antacids are bases and act by neutralizing stomach acid.
They do not give much credit to the claims made for the various antacids and they claim that the old home remedy, sodium bicarbonate, is safe and effective as an antacid if not used is excess. The concentration of hcl in simulated gastric acid is 0. Hydrochloric acid hcl is one of the substances found in gastric juices secreted by the lining of the. To compare the palatability, acid consuming capacity and cost effectiveness of different brands of liquid antacids available in karachi. To analyze the given samples of commercial antacids by determining the amount of hydrochloric acid they can neutralize. Five different but widely used commercial antacid tablets were selected for the purpose of this study. Then add drop by drop and stir it after every drop. Antacids are substances that consist of weak bases commonly hydroxide, and carbonate. The action of antacids is based on the fact that a base can neutralize an acid forming salt and water. Side effects from antacids vary depending on individual and other medications they may be taking at the time. The static analysis revealed that there was a significant difference of anc in favor of rennie versus other antacid tablets studied. This happens when these nerves are exposed, as in peptic ulcers.
A number of commercial antacids are available to neutralize the excess acid. Common antacids satisfy the condition right amount of alkali that can neutralize the acid. Chemistry investigatory project comparitive study of commercial antacids a project report submitted by. The purpose of this study is to evaluate the effect of pharmaceutical properties on the anc of antacid oral suspensions. Jan 29, 2014 some more side effects fortunately, because acid reflux is such a common problem, antacids are among the medicines available and free of side effects for most people. Discussion inthe present study, wetested fourantacidswitha wide range of composition, embracing most ofthe. This is the project work on comparitive study of commercial antacids as prescribed by cbse, india in partial fulfillment of grade 12.
If the content of alkali in the antacid is too high, no doubt acidity is relieved. Determination of acid neutralising power of a commercial antacid tablet. Up to onethird of the population suffer from dyspepsia and up to twothirds of all patients rely on selfmedication. Nine in vitro methods commonly used to evaluate antacids were compared on several types of antacids. It is widely used to study comparative study of commercial antacids such as the hourscure vastukosha macedonias attributions can be fatal to workers because it can paralyze the respiratory view. The number of moles of acid that can be neutralized by a single tablet of a commercial antacid will be determined by back titration.
No direct correlation could be made to reduce all the methods to a common denominator. The effect of pharmaceutical properties on the acid. Start studying antacids learn vocabulary, terms, and more with flashcards, games, and other study tools. Evaluatingcommercialantacids evaluating commercial antacids. Different types of antacid tables may be studied in your class. Comparitive study of commercial antacidscbse class 12 project free download as word doc. By signing up, youll get thousands of stepbystep solutions to your homework questions. Acids can back up in the stomach and flow up into the esophagus, causing heartburn. Jul 24, 2018 evaluating the efficacy of antacids quah jing wen. Pdf comparative study among the different formulation of. Pure water is said to be neutral, with a ph close to 7.
When gastric hydrochloric acid reaches the nerves in the gastrointestinal mucosa, they signal pain to the central nervous system. Stomach acid, also called gastric acid, is a digestive fluid that contains, among other things, hydrochloric acid hcl, 36. Antacids may be divided into two classes, those that work by chemical neutralization of gastric acid, most notably sodium bicarbonate and those that act by adsorption of the acid nonabsorbable antacids, such as calcium and magnesium slats like magnesium hydroxide, magnesium trisilicate, calcium carbonate, etc. Tantosh and others published comparative study of the acid neutralizing capacity of various commercially available antacid formulations in libya. Georgia baldus experiment purpose chemical antacids natural antacids tums gaviscon alkaseltzer pepcid goat milk soy milk cinnamon turmeric ginger root chamomile tea green tea black tea acid refluxinduced asthma many prescriptions never tried.
Based on information from carpi, i know that acids and bases create salt and water when theyre mixed together 2003. Pdf comparative study of the acid neutralizing capacity of. Whenallowance was made for equivalent buffering capacities, the cost was lowest for preparation dtable 3. Comparative study among the different formulation of antacid tablets by using acidbase neutralization reaction article pdf available in global journal of pharmacology 93. Antacid medicines introduction antacids are a type of medication that can control the acid levels in your stomach.
Jan 09, 2018 most of us know how hard it is to resist the creamy sweetness of ice cream. However, for a number of reasons the stomach may secrete excess hydrochloric acid that causes discomfort. A comparative study of the acid neutralizing capacity of. If i test equate brand antacids and rolaids extra strength antacids, then they should both neutralize the same amount of hcl acid because they both have 675 mg of calcium carbonate and 5 mg of magnesium hydroxide. An antacid is any substance, generally a base or basic salt, which neutralizes stomach acidity. Comparitive study of commercial antacidscbse class 12. Effectiveness of commercial antacids introduction ph is a measure of the acidity or basicity of an aqueous solution. Evaluation of neutralizing capacity of different commercial. Sep 28, 2016 evaluating commercial antacids introduction the purpose of the lab was to determine the number of moles of hydrochloric acid neutralized by a commercial antacid tablet. This may be caused by spicy or fatty foods, eating before bed, over drinking, stress and smoking. Apr 30, 2018 antacids are used to relieve the symptoms of gastroesophageal reflux disease, heartburn or indigestion.
How would you measure active ingredients in a commercial antacid. In this experiment, several brands of antacid tablets will be compared for their capacity to. Fifteen antacid oral suspensions randomly sourced from different manufacturers and coded a1a15 were assessed using anc, raft formation, sedimentation profiles, ease of. If you do not understand how to do this after reading the background material, seek assistance. By neutralizing stomach acid, they relieve symptoms such as burning in the chest or throat area caused by acid reflux, a bitter taste in the mouth, a persistent dry cough, pain when lying down, and regurgitation. A comparative in vivo study of antacids ii sciencedirect. Registered users can save articles, searches, and manage email alerts.
Antacids are commercial products that neutralize the excess acid in the stomach providing a sensation of relief to the person. This article has been cited by other articles in pmc. Chem project class 12 with investigatory project on. Determine the acid neutralizing power of two commercial antacids and how the two compare. One method of evaluating antacid preparations is to determine the number of moles of hcl that will react with a known mass of antacid.